{"id":155119,"date":"2026-07-15T13:23:59","date_gmt":"2026-07-15T13:23:59","guid":{"rendered":"https:\/\/pabau.com\/?p=155119"},"modified":"2026-08-13T11:10:07","modified_gmt":"2026-08-13T11:10:07","slug":"17-hydroxyprogesterone-test","status":"publish","type":"post","link":"https:\/\/pabau.com\/nl\/templates\/17-hydroxyprogesterone-test\/","title":{"rendered":"17-hydroxyprogesterone test"},"content":{"rendered":"\n<script type=\"application\/ld+json\">{\"@context\":\"https:\/\/schema.org\",\"@type\":\"MedicalWebPage\",\"headline\":\"17-Hydroxyprogesterone Test: Clinical Reference Guide for Practitioners\",\"description\":\"Clinical reference guide for the 17-hydroxyprogesterone (17-OHP) test: indications for CAH and PCOS diagnosis, reference ranges by age and sex, CPT code 83498, specimen requirements, and interpretation for healthcare practitioners.\",\"url\":\"https:\/\/pabau.com\/templates\/17-hydroxyprogesterone-test\/\",\"audience\":{\"@type\":\"MedicalAudience\",\"audienceType\":\"Clinician\"},\"reviewedBy\":{\"@type\":\"Person\",\"name\":\"Dr Vanja Kitanova\",\"jobTitle\":\"Medical Reviewer\",\"affiliation\":{\"@type\":\"Organization\",\"name\":\"Pabau\"},\"knowsAbout\":[\"Medical Coding\",\"Clinical Documentation\",\"Healthcare Billing\",\"Clinical Safety\",\"Endocrinology\"],\"sameAs\":\"https:\/\/pabau.com\/blog\/author\/vanja\/\"},\"mainEntity\":{\"@type\":\"DigitalDocument\",\"name\":\"17-Hydroxyprogesterone Test\",\"description\":\"A clinical reference template for ordering and interpreting the 17-hydroxyprogesterone (17-OHP) test, covering diagnostic indications (CAH, PCOS, adrenal disorders), reference ranges by age and sex, specimen collection timing, and result interpretation thresholds.\",\"encodingFormat\":\"application\/pdf\",\"url\":\"https:\/\/cdn.pabau.com\/cdn\/attachments\/pulse\/content-engine\/templates\/17-hydroxyprogesterone-test\/17-hydroxyprogesterone-test.pdf\",\"inLanguage\":\"en\",\"isAccessibleForFree\":true,\"offers\":{\"@type\":\"Offer\",\"price\":\"0\",\"priceCurrency\":\"GBP\",\"availability\":\"https:\/\/schema.org\/InStock\"},\"hasDigitalDocumentPermission\":{\"@type\":\"DigitalDocumentPermission\",\"permissionType\":\"https:\/\/schema.org\/ReadPermission\"},\"author\":{\"@type\":\"Organization\",\"name\":\"Pabau\",\"url\":\"https:\/\/www.pabau.com\"},\"datePublished\":\"2026-07-15\"},\"datePublished\":\"2026-07-15\",\"dateModified\":\"2026-07-15\"}<\/script>\n\n\n        <div id=\"key_takeaways\">\n            <div class=\"header\">\n                                    <img decoding=\"async\" src=\"https:\/\/pabau.com\/wp-content\/uploads\/2025\/12\/Key-Takeaways-Icon.svg\" alt=\"Key Takeaways\" height=\"42\" width=\"42\">\n                                <h3>Key Takeaways<\/h3>\n            <\/div>\n            <div class=\"list\">\n                                                            <div class=\"item\">\n                            <div>\n                                <svg width=\"20\" height=\"27\" viewBox=\"0 0 20 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                                    <path\n                                        d=\"M18.6223 14.3857C19.1246 13.8975 19.1246 13.1045 18.6223 12.6162L12.1938 6.36621C11.6915 5.87793 10.8759 5.87793 10.3737 6.36621C9.87143 6.85449 9.87143 7.64746 10.3737 8.13574L14.6125 12.2529H2.28571C1.57455 12.2529 1 12.8115 1 13.5029C1 14.1943 1.57455 14.7529 2.28571 14.7529H14.6085L10.3777 18.8701C9.87545 19.3584 9.87545 20.1514 10.3777 20.6396C10.8799 21.1279 11.6955 21.1279 12.1978 20.6396L18.6263 14.3896L18.6223 14.3857Z\"\n                                        fill=\"#3D3D46\" \/>\n                                <\/svg>\n                            <\/div>\n                            <p>17-hydroxyprogesterone (17-OHP) is a hormone precursor in the adrenal cortex; elevated levels indicate 21-hydroxylase deficiency and congenital adrenal hyperplasia (CAH).<\/p>\n                        <\/div>\n                                                                                <div class=\"item\">\n                            <div>\n                                <svg width=\"20\" height=\"27\" viewBox=\"0 0 20 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                                    <path\n                                        d=\"M18.6223 14.3857C19.1246 13.8975 19.1246 13.1045 18.6223 12.6162L12.1938 6.36621C11.6915 5.87793 10.8759 5.87793 10.3737 6.36621C9.87143 6.85449 9.87143 7.64746 10.3737 8.13574L14.6125 12.2529H2.28571C1.57455 12.2529 1 12.8115 1 13.5029C1 14.1943 1.57455 14.7529 2.28571 14.7529H14.6085L10.3777 18.8701C9.87545 19.3584 9.87545 20.1514 10.3777 20.6396C10.8799 21.1279 11.6955 21.1279 12.1978 20.6396L18.6263 14.3896L18.6223 14.3857Z\"\n                                        fill=\"#3D3D46\" \/>\n                                <\/svg>\n                            <\/div>\n                            <p>Specimen is serum collected during follicular phase in females; CPT code 83498 applies; methodology is LC\/MS or HPLC-MS\/MS.<\/p>\n                        <\/div>\n                                                                                <div class=\"item\">\n                            <div>\n                                <svg width=\"20\" height=\"27\" viewBox=\"0 0 20 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                                    <path\n                                        d=\"M18.6223 14.3857C19.1246 13.8975 19.1246 13.1045 18.6223 12.6162L12.1938 6.36621C11.6915 5.87793 10.8759 5.87793 10.3737 6.36621C9.87143 6.85449 9.87143 7.64746 10.3737 8.13574L14.6125 12.2529H2.28571C1.57455 12.2529 1 12.8115 1 13.5029C1 14.1943 1.57455 14.7529 2.28571 14.7529H14.6085L10.3777 18.8701C9.87545 19.3584 9.87545 20.1514 10.3777 20.6396C10.8799 21.1279 11.6955 21.1279 12.1978 20.6396L18.6263 14.3896L18.6223 14.3857Z\"\n                                        fill=\"#3D3D46\" \/>\n                                <\/svg>\n                            <\/div>\n                            <p>Reference ranges vary by age, sex, and menstrual phase: follicular females 15-70 ng\/dL, luteal 35-290 ng\/dL, males 27-199 ng\/dL.<\/p>\n                        <\/div>\n                                                                                <div class=\"item\">\n                            <div>\n                                <svg width=\"20\" height=\"27\" viewBox=\"0 0 20 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                                    <path\n                                        d=\"M18.6223 14.3857C19.1246 13.8975 19.1246 13.1045 18.6223 12.6162L12.1938 6.36621C11.6915 5.87793 10.8759 5.87793 10.3737 6.36621C9.87143 6.85449 9.87143 7.64746 10.3737 8.13574L14.6125 12.2529H2.28571C1.57455 12.2529 1 12.8115 1 13.5029C1 14.1943 1.57455 14.7529 2.28571 14.7529H14.6085L10.3777 18.8701C9.87545 19.3584 9.87545 20.1514 10.3777 20.6396C10.8799 21.1279 11.6955 21.1279 12.1978 20.6396L18.6263 14.3896L18.6223 14.3857Z\"\n                                        fill=\"#3D3D46\" \/>\n                                <\/svg>\n                            <\/div>\n                            <p>Practice management software like Pabau keeps digital forms and client records in one place, streamlining test ordering and result documentation for CAH, PCOS, and adrenal disorder workups.<\/p>\n                        <\/div>\n                                                <\/div>\n        <\/div>\n    \n\n\n<h2 id=\"h-download-your-free-17-hydroxyprogesterone-test-reference-guide\" class=\"wp-block-heading\">Download your free 17-hydroxyprogesterone test reference guide<\/h2>\n\n\n\n<div style=\"background: linear-gradient(135deg, #E2F2FD 0%, #DFE3FD 100%); border-radius: 16px; padding: 40px; margin: 32px 0;\">\n<h2 style=\"margin: 0 0 12px 0; font-size: 22px; color: #121d36;\">17-Hydroxyprogesterone test<\/h2>\n<p style=\"margin: 0 0 20px 0; color: #444; font-size: 15px;\">A ready-to-use clinical reference covering test indications, reference ranges by age and sex, specimen collection requirements, CPT code 83498, and result interpretation thresholds for CAH, PCOS, and adrenal disorder evaluation.<\/p>\n<a style=\"display: inline-block; background: #037CD2; color: #fff; padding: 14px 28px; border-radius: 8px; text-decoration: none; font-weight: 600; font-size: 15px;\" href=\"https:\/\/cdn.pabau.com\/cdn\/attachments\/pulse\/content-engine\/templates\/17-hydroxyprogesterone-test\/17-hydroxyprogesterone-test.pdf\" target=\"_blank\" rel=\"noopener\">Download template<\/a>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\">The 17-hydroxyprogesterone test is a cornerstone diagnostic for endocrine conditions affecting reproductive health and adrenal function. This clinical reference guide provides practitioners with essential ordering, interpretation, and documentation information for one of the most frequently ordered hormone tests.<\/p>\n\n\n\n<h2 id=\"h-what-is-the-17-hydroxyprogesterone-test\" class=\"wp-block-heading\">What is the 17-hydroxyprogesterone test?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The 17-hydroxyprogesterone (17-OHP) test measures serum levels of 17-hydroxyprogesterone, a hormone intermediate in the cortisol biosynthesis pathway. Produced by the adrenal cortex, this hormone precursor accumulates when the enzyme 21-hydroxylase is deficient or dysfunctional, making 17-OHP measurement the gold standard screening for congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The 17-hydroxyprogesterone test is ordered to evaluate adrenal steroidogenesis, screen newborns for CAH, investigate hyperandrogenic symptoms in reproductive-age females, and assess suspected adrenal insufficiency in adults. It is not a standalone diagnostic but part of a broader hormone panel.<\/p>\n\n\n\n<h2 id=\"h-clinical-uses-and-indications-for-17-hydroxyprogesterone-testing\" class=\"wp-block-heading\">Clinical uses and indications for 17-hydroxyprogesterone testing<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The 17-hydroxyprogesterone test serves multiple diagnostic roles across pediatric and adult medicine:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Congenital adrenal hyperplasia (CAH) diagnosis and monitoring:<\/strong> Elevated 17-OHP is the diagnostic marker for 21-hydroxylase deficiency, the most common CAH form (>90% of cases). Serial testing monitors disease control during treatment.<\/li>\n\n\n\n<li><strong>Newborn screening:<\/strong> Mandatory in all US states and many international jurisdictions; identifies neonates at risk for classic CAH presenting with adrenal crisis.<\/li>\n\n\n\n<li><strong>Polycystic ovary syndrome (PCOS) evaluation:<\/strong> Elevated 17-OHP (non-classic CAH range) occurs in 20-30% of PCOS patients; exclusion of non-classic CAH is part of differential diagnosis.<\/li>\n\n\n\n<li><strong>Hirsutism and hyperandrogenism workup:<\/strong> Elevated androgens with abnormal 17-OHP point to adrenal source rather than ovarian.<\/li>\n\n\n\n<li><strong>Adrenal tumor suspicion:<\/strong> Severely elevated 17-OHP may indicate adrenal cortical neoplasm; imaging follows abnormal results.<\/li>\n\n\n\n<li><strong>Adrenal insufficiency evaluation:<\/strong> Low 17-OHP in the context of low cortisol suggests primary adrenal failure.<\/li>\n<\/ul>\n\n\n\n<h2 id=\"h-test-methodology-and-specimen-requirements\" class=\"wp-block-heading\">Test methodology and specimen requirements<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Modern 17-hydroxyprogesterone testing uses liquid chromatography tandem mass spectrometry (LC\/MS or HPLC-MS\/MS), which provides superior specificity and accuracy compared to immunoassay. Immunoassay can produce falsely elevated results in neonates due to cross-reactivity with other steroids. LC\/MS avoids this pitfall.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Specimen type is serum, not plasma. Collection timing is critical for reproductive-age females. Early follicular phase, days 3-5 of the menstrual cycle, is the standard for comparing results to published reference intervals. Post-ovulation (luteal phase) collections show 3-5 fold higher 17-OHP due to the progesterone rise. If luteal-phase results come back, interpret them against luteal reference ranges, not follicular. Specimen stability is approximately 14 days refrigerated. Verify this with your specific laboratory.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pabau.com\/features\/capture-forms-software\/\">Clinical form capture tools<\/a> let staff complete assessments like this on a tablet during the session itself.<\/p>\n\n\n\n<h2 id=\"h-cpt-code-and-billing-information\" class=\"wp-block-heading\">CPT code and billing information<\/h2>\n\n\n\n<table style=\"width:100%;border-collapse:separate;border-spacing:0;border-radius:12px;overflow:hidden;font-size:15px;line-height:1.5;margin:1.5em 0 2em;box-shadow:0 2px 12px rgba(0,0,0,0.08)\">\n<thead>\n<tr>\n<th style=\"background:#121D36;color:#fff;padding:14px 16px;text-align:left;font-weight:600;font-size:14px;letter-spacing:0.3px;border-bottom:2px solid #2BADD4\">Billing Code<\/th>\n<th style=\"background:#121D36;color:#fff;padding:14px 16px;text-align:left;font-weight:600;font-size:14px;letter-spacing:0.3px;border-bottom:2px solid #2BADD4\">Code Value<\/th>\n<th style=\"background:#121D36;color:#fff;padding:14px 16px;text-align:left;font-weight:600;font-size:14px;letter-spacing:0.3px;border-bottom:2px solid #2BADD4\">Lab\/Notes<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:12px 16px;font-weight:600;color:#121D36\">CPT Code<\/td>\n<td style=\"padding:12px 16px;color:#374151\">83498<\/td>\n<td style=\"padding:12px 16px;color:#374151\">Standard procedural code for 17-OHP quantification<\/td>\n<\/tr>\n<tr style=\"background:#F9FAFB\">\n<td style=\"padding:12px 16px;font-weight:600;color:#121D36\">Labcorp Order Code<\/td>\n<td style=\"padding:12px 16px;color:#374151\">070085<\/td>\n<td style=\"padding:12px 16px;color:#374151\">17-OH Progesterone, LC\/MS<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:12px 16px;font-weight:600;color:#121D36\">Quest Diagnostics Test #<\/td>\n<td style=\"padding:12px 16px;color:#374151\">17180<\/td>\n<td style=\"padding:12px 16px;color:#374151\">17-Hydroxyprogesterone<\/td>\n<\/tr>\n<tr style=\"background:#F9FAFB\">\n<td style=\"padding:12px 16px;font-weight:600;color:#121D36\">ARUP Test Code<\/td>\n<td style=\"padding:12px 16px;color:#374151\">0092332<\/td>\n<td style=\"padding:12px 16px;color:#374151\">17-Hydroxyprogesterone Quantitative by HPLC-MS\/MS<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:12px 16px;font-weight:600;color:#121D36\">ICD-10 Indications (examples)<\/td>\n<td style=\"padding:12px 16px;color:#374151\">E25.0, E28.2, Z13.79<\/td>\n<td style=\"padding:12px 16px;color:#374151\">CAH, PCOS, screening encounter<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n<p class=\"wp-block-paragraph\">CPT code 83498 is the standard procedural code for 17-hydroxyprogesterone quantification. Reimbursement varies by payer and indication. Verify coverage with the patient&#8217;s insurance before ordering. Newborn screening tests are typically covered by state programs and not billed to insurance.<\/p>\n\n\n\n<h2 id=\"h-reference-ranges-by-age-sex-and-menstrual-phase\" class=\"wp-block-heading\">Reference ranges by age, sex, and menstrual phase<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">17-OHP reference ranges vary significantly by age, sex, and reproductive status. Results must be interpreted against age- and sex-matched reference intervals. Using the wrong range leads to misinterpretation.<\/p>\n\n\n\n<table style=\"width:100%;border-collapse:separate;border-spacing:0;border-radius:12px;overflow:hidden;font-size:15px;line-height:1.5;margin:1.5em 0 2em;box-shadow:0 2px 12px rgba(0,0,0,0.08)\">\n<thead>\n<tr>\n<th style=\"background:#121D36;color:#fff;padding:14px 16px;text-align:left;font-weight:600;font-size:14px;letter-spacing:0.3px;border-bottom:2px solid #2BADD4\">Population<\/th>\n<th style=\"background:#121D36;color:#fff;padding:14px 16px;text-align:left;font-weight:600;font-size:14px;letter-spacing:0.3px;border-bottom:2px solid #2BADD4\">Reference Range (ng\/dL)<\/th>\n<th style=\"background:#121D36;color:#fff;padding:14px 16px;text-align:left;font-weight:600;font-size:14px;letter-spacing:0.3px;border-bottom:2px solid #2BADD4\">Reference Range (nmol\/L)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:12px 16px;font-weight:600;color:#121D36\">Adult females, follicular phase<\/td>\n<td style=\"padding:12px 16px;color:#374151\">15-70<\/td>\n<td style=\"padding:12px 16px;color:#374151\">0.45-2.1<\/td>\n<\/tr>\n<tr style=\"background:#F9FAFB\">\n<td style=\"padding:12px 16px;font-weight:600;color:#121D36\">Adult females, luteal phase<\/td>\n<td style=\"padding:12px 16px;color:#374151\">35-290<\/td>\n<td style=\"padding:12px 16px;color:#374151\">1.0-8.8<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:12px 16px;font-weight:600;color:#121D36\">Adult females, postmenopausal<\/td>\n<td style=\"padding:12px 16px;color:#374151\">7-40<\/td>\n<td style=\"padding:12px 16px;color:#374151\">0.2-1.2<\/td>\n<\/tr>\n<tr style=\"background:#F9FAFB\">\n<td style=\"padding:12px 16px;font-weight:600;color:#121D36\">Adult males<\/td>\n<td style=\"padding:12px 16px;color:#374151\">27-199<\/td>\n<td style=\"padding:12px 16px;color:#374151\">0.8-6.0<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:12px 16px;font-weight:600;color:#121D36\">Prepubertal children (both sexes)<\/td>\n<td style=\"padding:12px 16px;color:#374151\">5-50<\/td>\n<td style=\"padding:12px 16px;color:#374151\">0.15-1.5<\/td>\n<\/tr>\n<tr style=\"background:#F9FAFB\">\n<td style=\"padding:12px 16px;font-weight:600;color:#121D36\">Neonates (0-3 days)<\/td>\n<td style=\"padding:12px 16px;color:#374151\">200-1,000+<\/td>\n<td style=\"padding:12px 16px;color:#374151\">6-30+<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Critical timing note for females:<\/strong> Menstrual cycle phase dramatically affects 17-OHP concentration. Follicular phase (days 3-5) values are lower. Luteal phase (7-10 days after ovulation) values can be 3-5 times higher due to corpus luteum progesterone synthesis. Always document collection date and menstrual cycle phase on requisition forms. Lab reference ranges account for these variations, so confirm your lab&#8217;s specific intervals.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Related templates<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/pabau.com\/templates\/alberta-infant-motor-scale-template\/\">Alberta Infant Motor Scale Template<\/a><\/li>\n\n\n<li><a href=\"https:\/\/pabau.com\/templates\/2-minute-step-test\/\">2-Minute step test<\/a><\/li>\n\n\n<li><a href=\"https:\/\/pabau.com\/templates\/30-second-chair-stand-test\/\">30-Second chair stand test<\/a><\/li>\n\n\n<li><a href=\"https:\/\/pabau.com\/templates\/36-item-short-form-survey-sf-36\/\">SF-36 questionnaire template<\/a><\/li>\n<\/ul>\n\n\n        <div id=\"book_a_demo\">\n            <div class=\"left-side\">\n                <div class=\"logo\">\n                    <img decoding=\"async\"\n                        src=\"https:\/\/pabau.com\/wp-content\/uploads\/2026\/01\/Logo.svg\"\n                        alt=\"Logo\"\n                        loading=\"lazy\"\n                    \/>\n                <\/div>\n\n                <h3 class=\"heading\">\n                    Streamline your test ordering and result documentation                <\/h3>\n\n                <p class=\"description\">\n                    Pabau&#8217;s digital forms and integrated client records keep hormone test requisitions, results, and clinical notes organized in one searchable system.                <\/p>\n\n                <div class=\"button-group\">\n                    <a href=\"\/book-demo\/\" class=\"btn btn-scale-effect btn-cta-color btn-md\">\n                        <span class=\"btn-text\">Book a demo<\/span>\n                        <div class=\"btn-icon btn-icon-right\" aria-hidden=\"true\">\n                            <svg\n                                width=\"14\"\n                                height=\"12\"\n                                viewBox=\"0 0 14 12\"\n                                fill=\"none\"\n                                xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\n                            >\n                                <path\n                                    d=\"M0.75 4.77295C0.335786 4.77295 0 5.10874 0 5.52295C0 5.93716 0.335786 6.27295 0.75 6.27295V5.52295V4.77295ZM13.2803 6.05328C13.5732 5.76039 13.5732 5.28551 13.2803 4.99262L8.50736 0.219648C8.21447 -0.073245 7.73959 -0.073245 7.4467 0.219648C7.15381 0.512542 7.15381 0.987415 7.4467 1.28031L11.6893 5.52295L7.4467 9.76559C7.15381 10.0585 7.15381 10.5334 7.4467 10.8263C7.73959 11.1191 8.21447 11.1191 8.50736 10.8263L13.2803 6.05328ZM0.75 5.52295V6.27295L12.75 6.27295V5.52295V4.77295L0.75 4.77295V5.52295Z\"\n                                    fill=\"currentColor\"\n                                ><\/path>\n                            <\/svg>\n                        <\/div>\n                    <\/a>\n                <\/div>\n            <\/div>\n\n            <div class=\"right-side\">\n                <img decoding=\"async\"\n                    src=\"https:\/\/pabau.com\/wp-content\/uploads\/2026\/01\/Home-Page-Concept-4.webp\"\n                    alt=\"Pabau clinical dashboard\"\n                    loading=\"lazy\"\n                \/>\n            <\/div>\n        <\/div>\n        \n\n\n<h2 id=\"h-interpreting-test-results\" class=\"wp-block-heading\">Interpreting test results<\/h2>\n\n\n\n<h3 id=\"h-high-17-hydroxyprogesterone-in-females\" class=\"wp-block-heading\">High 17-hydroxyprogesterone in females<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Elevated 17-OHP in reproductive-age females indicates potential adrenal or ovarian dysfunction. Clinical interpretation depends on degree of elevation and concurrent symptoms.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Classic CAH (17-OHP typically >1,000-2,000 ng\/dL):<\/strong> Homozygous or compound heterozygous 21-hydroxylase deficiency; presents in infancy with virilization (females) or salt-wasting adrenal crisis (both sexes). Requires lifelong glucocorticoid and mineralocorticoid replacement.<\/li>\n\n\n\n<li><strong>Non-classic CAH (17-OHP typically 150-400 ng\/dL):<\/strong> Mild enzyme deficiency; adult presentation with hirsutism, irregular periods, infertility, or metabolic dysfunction. More common in PCOS phenotype populations.<\/li>\n\n\n\n<li><strong>PCOS with adrenal hyperresponsiveness:<\/strong> 17-OHP in the 100-150 ng\/dL range during follicular phase may indicate exaggerated adrenal androgen response to ACTH; often coexists with ovarian hyperandrogenism.<\/li>\n\n\n\n<li><strong>Adrenal tumors:<\/strong> Markedly elevated 17-OHP (>500 ng\/dL) with concurrent very high cortisol or DHEA-S suggests adrenal cortical neoplasm; imaging (CT\/MRI) is indicated.<\/li>\n<\/ul>\n\n\n\n<h3 id=\"h-low-17-hydroxyprogesterone-in-females\" class=\"wp-block-heading\">Low 17-hydroxyprogesterone in females<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Low 17-OHP is less commonly clinically significant but may indicate adrenal insufficiency when concurrent with low cortisol and elevated ACTH. Postmenopausal females naturally have lower 17-OHP due to decreased ovarian and adrenal hormone production. Medications, such as glucocorticoids and hormonal contraceptives, suppress 17-OHP. Document medication use on requisition.<\/p>\n\n\n\n<h2 id=\"h-17-ohp-in-newborn-screening\" class=\"wp-block-heading\">17-OHP in newborn screening<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Elevated 17-OHP on newborn screening (heel-stick dried blood spot) is the primary marker for CAH in neonates. Screening cutoffs vary by state, typically 30-60 ng\/dL depending on assay and birth weight, and are optimized to detect classic CAH while minimizing false positives. Transiently elevated 17-OHP is common in sick neonates, low-birth-weight infants, and premature babies. Confirmatory testing, including serum 17-OHP, ACTH, cortisol, and electrolytes, is always performed before diagnosis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Diagnosis of neonatal CAH initiates immediate glucocorticoid therapy to prevent adrenal crisis and reduce virilization exposure in affected females. <\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/cdn.pabau.com\/cdn\/attachments\/pulse\/content-engine\/downloadable_template_article\/17-hydroxyprogesterone-test\/detailed-client-records-in-pabau.webp\" alt=\"Detailed client records in Pabau\"\/><figcaption class=\"wp-element-caption\"><em>Detailed client records in Pabau<\/em><\/figcaption><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 id=\"h-17-hydroxyprogesterone-and-fertility\" class=\"wp-block-heading\">17-Hydroxyprogesterone and fertility<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">17-OHP monitoring is integral to fertility assessment and treatment in reproductive medicine. Non-classic CAH, detected via elevated 17-OHP, impairs fertility through irregular ovulation, elevated androgens, and abnormal endometrial development. Screening for non-classic CAH is recommended in women with infertility and hirsutism, as glucocorticoid treatment can restore ovulatory cycles.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In fertility treatment cycles, 17-OHP is sometimes measured during baseline assessment to stratify risk for poor ovarian response. Practitioners order the test during follicular phase before cycle initiation to establish baseline adrenal and ovarian steroid function.<\/p>\n\n\n\n<h2 id=\"h-how-to-order-this-test-quick-reference-for-clinicians\" class=\"wp-block-heading\">How to order this test: Quick reference for clinicians<\/h2>\n\n\n\n<table style=\"width:100%;border-collapse:separate;border-spacing:0;border-radius:12px;overflow:hidden;font-size:15px;line-height:1.5;margin:1.5em 0 2em;box-shadow:0 2px 12px rgba(0,0,0,0.08)\">\n<thead>\n<tr>\n<th style=\"background:#121D36;color:#fff;padding:14px 16px;text-align:left;font-weight:600;font-size:14px;letter-spacing:0.3px;border-bottom:2px solid #2BADD4\">Component<\/th>\n<th style=\"background:#121D36;color:#fff;padding:14px 16px;text-align:left;font-weight:600;font-size:14px;letter-spacing:0.3px;border-bottom:2px solid #2BADD4\">Specification<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:12px 16px;font-weight:600;color:#121D36\">Specimen Type<\/td>\n<td style=\"padding:12px 16px;color:#374151\">Serum (SST tube preferred; avoid EDTA\/lavender top)<\/td>\n<\/tr>\n<tr style=\"background:#F9FAFB\">\n<td style=\"padding:12px 16px;font-weight:600;color:#121D36\">Collection Timing (females)<\/td>\n<td style=\"padding:12px 16px;color:#374151\">Early follicular phase (days 3-5 of cycle) for standardized comparison; note cycle day on requisition<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:12px 16px;font-weight:600;color:#121D36\">Collection Timing (males\/children\/newborns)<\/td>\n<td style=\"padding:12px 16px;color:#374151\">Any time; no cycle-phase restriction<\/td>\n<\/tr>\n<tr style=\"background:#F9FAFB\">\n<td style=\"padding:12px 16px;font-weight:600;color:#121D36\">Volume Required<\/td>\n<td style=\"padding:12px 16px;color:#374151\">0.5-1 mL serum (verify with specific lab)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:12px 16px;font-weight:600;color:#121D36\">Stability<\/td>\n<td style=\"padding:12px 16px;color:#374151\">Refrigerated 14 days; frozen up to 1 year<\/td>\n<\/tr>\n<tr style=\"background:#F9FAFB\">\n<td style=\"padding:12px 16px;font-weight:600;color:#121D36\">Methodology<\/td>\n<td style=\"padding:12px 16px;color:#374151\">LC\/MS or HPLC-MS\/MS (gold standard; preferred over immunoassay)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:12px 16px;font-weight:600;color:#121D36\">CPT Code<\/td>\n<td style=\"padding:12px 16px;color:#374151\">83498<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n<p class=\"wp-block-paragraph\">Document the following on the requisition to ensure accurate lab interpretation and reference range selection:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Patient age and sex<\/li>\n\n\n\n<li>Menstrual cycle phase, if female<\/li>\n\n\n\n<li>Current medications, especially glucocorticoids and oral contraceptives<\/li>\n\n\n\n<li>Clinical indication, such as CAH screening, PCOS evaluation, or hirsutism workup<\/li>\n\n\n\n<li>Any recent illness<\/li>\n<\/ul>\n\n\n\n<h2 id=\"h-conclusion\" class=\"wp-block-heading\">Conclusion<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The 17-hydroxyprogesterone test is essential for diagnosing and monitoring adrenal disorders, CAH, PCOS, and fertility issues. Understanding reference ranges, collection timing, and result interpretation ensures clinically appropriate ordering and patient care. Download the template above to keep this reference at hand during clinical workflows and patient consultations.<\/p>\n\n\n        <div id=\"expert_picks\">\n            <div class=\"header\">\n                                    <img decoding=\"async\" src=\"https:\/\/pabau.com\/wp-content\/uploads\/2025\/11\/Expert-Picks.svg\" alt=\"Continue your research\" height=\"42\" width=\"42\">\n                                <h3>Continue your research<\/h3>\n            <\/div>\n            <div class=\"content\">\n                                                            <div class=\"item\">\n                            <div>\n                                <svg width=\"20\" height=\"27\" viewBox=\"0 0 20 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                                    <path\n                                        d=\"M18.6223 14.3857C19.1246 13.8975 19.1246 13.1045 18.6223 12.6162L12.1938 6.36621C11.6915 5.87793 10.8759 5.87793 10.3737 6.36621C9.87143 6.85449 9.87143 7.64746 10.3737 8.13574L14.6125 12.2529H2.28571C1.57455 12.2529 1 12.8115 1 13.5029C1 14.1943 1.57455 14.7529 2.28571 14.7529H14.6085L10.3777 18.8701C9.87545 19.3584 9.87545 20.1514 10.3777 20.6396C10.8799 21.1279 11.6955 21.1279 12.1978 20.6396L18.6263 14.3896L18.6223 14.3857Z\"\n                                        fill=\"#54B2D3\" \/>\n                                <\/svg>\n                            <\/div>\n                            <p><strong>Monitoring ovarian response during fertility treatment?<\/strong> <a href=\"https:\/\/pabau.com\/templates\/doppler-ultrasound-report\/\">Doppler ultrasound report<\/a> template documents imaging findings alongside hormone results.<\/p>\n                        <\/div>\n                                                                                <div class=\"item\">\n                            <div>\n                                <svg width=\"20\" height=\"27\" viewBox=\"0 0 20 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                                    <path\n                                        d=\"M18.6223 14.3857C19.1246 13.8975 19.1246 13.1045 18.6223 12.6162L12.1938 6.36621C11.6915 5.87793 10.8759 5.87793 10.3737 6.36621C9.87143 6.85449 9.87143 7.64746 10.3737 8.13574L14.6125 12.2529H2.28571C1.57455 12.2529 1 12.8115 1 13.5029C1 14.1943 1.57455 14.7529 2.28571 14.7529H14.6085L10.3777 18.8701C9.87545 19.3584 9.87545 20.1514 10.3777 20.6396C10.8799 21.1279 11.6955 21.1279 12.1978 20.6396L18.6263 14.3896L18.6223 14.3857Z\"\n                                        fill=\"#54B2D3\" \/>\n                                <\/svg>\n                            <\/div>\n                            <p><strong>Coordinating care for patients with concurrent endocrine conditions?<\/strong> <a href=\"https:\/\/pabau.com\/templates\/diabetes-nursing-care-plan\/\">Diabetes nursing care plan<\/a> template keeps metabolic monitoring organized alongside hormone panels.<\/p>\n                        <\/div>\n                                                                                <div class=\"item\">\n                            <div>\n                                <svg width=\"20\" height=\"27\" viewBox=\"0 0 20 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                                    <path\n                                        d=\"M18.6223 14.3857C19.1246 13.8975 19.1246 13.1045 18.6223 12.6162L12.1938 6.36621C11.6915 5.87793 10.8759 5.87793 10.3737 6.36621C9.87143 6.85449 9.87143 7.64746 10.3737 8.13574L14.6125 12.2529H2.28571C1.57455 12.2529 1 12.8115 1 13.5029C1 14.1943 1.57455 14.7529 2.28571 14.7529H14.6085L10.3777 18.8701C9.87545 19.3584 9.87545 20.1514 10.3777 20.6396C10.8799 21.1279 11.6955 21.1279 12.1978 20.6396L18.6263 14.3896L18.6223 14.3857Z\"\n                                        fill=\"#54B2D3\" \/>\n                                <\/svg>\n                            <\/div>\n                            <p><strong>Tracking long-term wellbeing in CAH or PCOS management?<\/strong> <a href=\"https:\/\/pabau.com\/templates\/quality-of-life-assessment\/\">Quality of life assessment<\/a> template gives a structured way to monitor patient-reported outcomes.<\/p>\n                        <\/div>\n                                                <\/div>\n        <\/div>\n    \n\n\n<h2 id=\"h-frequently-asked-questions\" class=\"wp-block-heading\">Frequently asked questions<\/h2>\n\n\n\n<div class=\"schema-faq wp-block-yoast-faq-block\"><div class=\"schema-faq-section\" id=\"faq-question-1\"><h3 class=\"schema-faq-question\">What is a 17-hydroxyprogesterone (17-OHP) test?<\/h3> <p class=\"schema-faq-answer\">The 17-hydroxyprogesterone test measures blood levels of 17-OHP, a hormone intermediate in cortisol production. Elevated 17-OHP indicates 21-hydroxylase enzyme deficiency and is the gold-standard diagnostic marker for congenital adrenal hyperplasia (CAH).<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-question-2\"><h3 class=\"schema-faq-question\">What does the 17-hydroxyprogesterone test for?<\/h3> <p class=\"schema-faq-answer\">The test screens for and diagnoses congenital adrenal hyperplasia (CAH), evaluates polycystic ovary syndrome (PCOS), investigates hirsutism and irregular periods, detects adrenal tumors, and assesses adrenal insufficiency in both adults and neonates.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-question-3\"><h3 class=\"schema-faq-question\">What is a normal 17-OH progesterone level in females?<\/h3> <p class=\"schema-faq-answer\">Normal adult female 17-OHP ranges from 15-70 ng\/dL during the follicular phase of the menstrual cycle; 35-290 ng\/dL during the luteal phase; and 7-40 ng\/dL if postmenopausal. Collection timing relative to the cycle is critical for interpretation.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-question-4\"><h3 class=\"schema-faq-question\">Why would a doctor order a 17-OHP test?<\/h3> <p class=\"schema-faq-answer\">Doctors order the 17-hydroxyprogesterone test when evaluating hirsutism, irregular cycles, infertility, newborn screening for CAH, suspected adrenal tumors, or monitoring CAH treatment response. It is also part of comprehensive hormonal panels for reproductive and metabolic assessment.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-question-5\"><h3 class=\"schema-faq-question\">Is the 17-OHP test used for newborn screening?<\/h3> <p class=\"schema-faq-answer\">Yes, elevated 17-OHP on newborn screening (heel-stick dried blood spot) is the primary marker for congenital adrenal hyperplasia. All US states and most developed countries include 17-OHP in mandatory newborn screening panels to detect and treat CAH before adrenal crisis occurs.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-question-6\"><h3 class=\"schema-faq-question\">What is the CPT code for the 17-hydroxyprogesterone test?<\/h3> <p class=\"schema-faq-answer\">CPT code 83498 is the standard billing code for 17-hydroxyprogesterone quantification. Labcorp uses order code 070085, Quest Diagnostics uses test number 17180, and ARUP uses test code 0092332.<\/p><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Download your free 17-hydroxyprogesterone test reference guide 17-Hydroxyprogesterone test A ready-to-use clinical reference covering test indications, reference ranges by age and sex, specimen collection requirements, CPT code 83498, and result interpretation thresholds for CAH, PCOS, and adrenal disorder evaluation. Download template The 17-hydroxyprogesterone test is a cornerstone diagnostic for endocrine conditions affecting reproductive health and [&hellip;]<\/p>\n","protected":false},"author":77,"featured_media":155118,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_yoast_wpseo_linkdex":"78","_yoast_wpseo_content_score":"60","_yoast_wpseo_is_cornerstone":"","_yoast_wpseo_keywordsynonyms":"[\"\",\"\",\"\",\"\",\"\",\"\"]","_yoast_wpseo_focuskw_text_input":"","_seo_original_html":"","footnotes":""},"categories":[1119,32,4138],"tags":[3944,2332,1155,2351,1382],"class_list":["post-155119","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-fertility","category-practice-management-tips","category-templates","tag-adrenal-insufficiency","tag-endocrine-testing","tag-fertility","tag-hormone-reference-ranges","tag-template"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin 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is an all-in-one healthcare practice management software platform designed for clinics, medspas, therapists, and medical professionals. It combines scheduling, electronic health records, clinical forms, payments, marketing automation, reporting, and patient engagement tools into one secure cloud system to help practices streamline operations and grow their business.\",\"foundingDate\":\"2011-10-20\",\"numberOfEmployees\":{\"@type\":\"QuantitativeValue\",\"minValue\":\"201\",\"maxValue\":\"500\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/pabau.com\\\/nl\\\/#\\\/schema\\\/person\\\/5de22f4ff3ec59b1925ef02dce956d7d\",\"name\":\"Katy Piper\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"nl-NL\",\"@id\":\"https:\\\/\\\/pabau.com\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/cropped-Snip20260306_177-96x96.png\",\"url\":\"https:\\\/\\\/pabau.com\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/cropped-Snip20260306_177-96x96.png\",\"contentUrl\":\"https:\\\/\\\/pabau.com\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/cropped-Snip20260306_177-96x96.png\",\"caption\":\"Katy Piper\"},\"description\":\"Katy Piper is a content writer covering aesthetics, dermatology, and clinic operations, with a knack for making clinical detail feel approachable. 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